California police are baffled when an innocent man's DNA is found at the scene of a deadly home invasion. Authorities team with the man's defense attorney to determine how the seemingly impossible could have happened.

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When the 20-year-old clerk of an Atlanta-area smoke shop is gunned down during a robbery, investigators have only descriptions of the killers and the make of their getaway car. Investigators used a videotaped confession to smoke out the killers.

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An upscale apparel store in Bethesda, MD was the site of a gruesome scene; a 30-year-old employee was dead and her 28-year-old co-worker was battered and tied up. Surveillance video would shed further light on the motive.

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Eight days after she had disappeared on her way to a family ski trip, an 18-year-old young woman's partially nude body is found floating in a river in Wyoming, Years later, DNA technology uncovers dark secrets that led to her demise.

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A young Colorado mother suddenly vanishes on Thanksgiving Day. When police trace her cell phone, it leads them to a surprising character with an even more surprising story.

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When a true-crime hobbyist connects a Utah Jane Doe to an Ohio missing persons case, detectives are hard-pressed to solve the decades-old murder.

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A family mourns the unexpected death of a beloved grandmother at Christmas. Local police assure everyone that she was a victim of a tragic accident and that there is no foul play. But some things about the scene just don't add up.

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July 4th weekend leads to tragedy for a California family. To catch a killer, detectives use an unorthodox technique -- analyzing bug fragments -- to help put a murderer behind bars.

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A 33-year-old West Virginia husband and father seemingly dies in an accidental house fire. But a closer look at the scene reveals a more sinister case.

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When the 18-year-old desk clerk of a beachfront condo is found brutally murdered analysts use brand-new mitochondrial DNA technology to prove the killer's identity.

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A Texas love triangle turns deadly, and it appears to be an open and shut case until technology tells the tale.

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